Orthohantavirus (or hantavirus) normally infects rodents, but does not cause disease in them. Humans may become infected with hantaviruses through contact with rodent urine, saliva, or feces, leading to death in one third of cases. As of January 2017, 728 cases of hantavirus disease have been reported since surveillance in the United States began in 1993. These are all laboratory-confirmed cases and include hantavirus pulmonary syndrome (HPS) and non-pulmonary hantavirus infection.