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Answer
Founded the Holy Roman Empire.
Charlemagne
First Norman King of England.
William the Conqueror
First leader of the Mongols.
Genghis Khan
Rich king from Mali who gave away lots of gold during his pilgrimage to Mecca.
Mansa Musa
Important female fighter who defended France from England during the Hundred Year's War. The English burned her at the stake when France was starting to win.
Joan of Arc
Leader of England during the Spanish Armada attack.
Elizabeth the First
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Answer
Famous playwright; writer of Romeo and Juliet.
William Shakespeare
Convinced Ferdinand and Isabella that he could go to Asia by sailing west.
Christopher Columbus
Famous Italian painter and scientist who painted the Mona Lisa.
There were many French kings and military commanders who defended their country during the Hundred Years' War. You might make the clue more specific for Joan of Arc.
This quiz assumes the Middle Ages lasted until the early 18th century (Newton) which would certainly have come as a surprise to people living in post-Renaissance Europe.